lab

The development of cerebellar function and its role in sensorimotor integration

Lab Members

Martijn Schonewille
Dr. Martijn Schonewille (M)
Full Professor
Lab Head
Catarina Osorio
Dr. Catarina Osorio
Assistant Professor
Hei Ling Lu
Hei Ling Lu
Phd Student
Jie Yang
Jie Yang
Phd Student
Zahra Hemmat
Zahra Hemmat
Phd Student
Gerco Beekhof
Mr. Gerco Beekhof
Phd Student
Simone Gherardi
Simone Gherardi
Master Student
Mariia Kolesnyk
Mariia Kolesnyk
Master Student
Efstathios Fantidis
Efstathios Fantidis
Master Student
Henrietta Serpescu
Henrietta Serpescu
Master Student
Nayaab Ahmad
Nayaab Ahmad
Bachelor Student
Nienke Gravendeel
Nienke Gravendeel
Bachelor Student
Laura Post
Laura Post
Research Technician
Chen Yang
Chen Yang
Scientific Researcher

Selected Publications

PP2B-dependent cerebellar plasticity sets the amplitude of the vestibulo-ocular reflex during juvenile development.

Wu B, Post L, Lin Z, Schonewille M
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2024

Purkinje cell microzones mediate distinct kinematics of a single movement.

Blot FGC, White JJ, van Hattem A, Scotti L, Balaji V, Adolfs Y, Pasterkamp RJ, De Zeeuw CI, Schonewille M
in Nature communications 2023

Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1

Catarina Osório, Joshua J White, Heiling Lu, Gerrit C Beekhof, Francesca Romana Fiocchi, Charlotte A Andriessen, Stephanie Dijkhuizen, Laura Post, Martijn Schonewille
in Brain 2023

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

Beekhof GC, Osório C, White JJ, van Zoomeren S, van der Stok H, Xiong B, Nettersheim IH, Mak WA, Runge M, Fiocchi FR, Boele HJ, Hoebeek FE, Schonewille M
in eLife 2021

Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice

blot
in 2021

Recent Publications

PP2B-dependent cerebellar plasticity sets the amplitude of the vestibulo-ocular reflex during juvenile development.

Wu B, Post L, Lin Z, Schonewille M
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2024

Lobule-Related Action Potential Shape- and History-Dependent Current Integration in Purkinje Cells of Adult and Developing Mice.

Beekhof GC, Schonewille M
in Cells 2023

cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.

Wang XT, Zhou L, Dong BB, Xu FX, Wang DJ, Shen EW, Cai XY, Wang Y, Wang N, Ji SJ, Chen W, Schonewille M, Zhu JJ, De Zeeuw CI, Shen Y
in eLife 2023

Purkinje cell microzones mediate distinct kinematics of a single movement.

Blot FGC, White JJ, van Hattem A, Scotti L, Balaji V, Adolfs Y, Pasterkamp RJ, De Zeeuw CI, Schonewille M
in Nature communications 2023

Publisher Correction: Purkinje cell microzones mediate distinct kinematics of a single movement.

Blot FGC, White JJ, van Hattem A, Scotti L, Balaji V, Adolfs Y, Pasterkamp RJ, De Zeeuw CI, Schonewille M
in Nature communications 2023

Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling

Fang-Xiao Xu, Xin-Tai Wang, Xin-Yu Cai, Jia-Yu Liu, Jing-Wen Guo, Fan Yang, Wei Chen, Martijn Schonewille, Chris De Zeeuw, Lin Zhou, Ying Shen
in Cell Reports 2023

Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1

Catarina Osório, Joshua J White, Heiling Lu, Gerrit C Beekhof, Francesca Romana Fiocchi, Charlotte A Andriessen, Stephanie Dijkhuizen, Laura Post, Martijn Schonewille
in Brain 2023

Reply to Piochon et al.: NMDARs in Purkinje cells are not involved in parallel fiber-Purkinje cell synaptic plasticity or motor learning.

Schonewille M, Girasole AE, De Zeeuw CI, Bouvier G
in Proceedings of the National Academy of Sciences of the United States of America 2022

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022

Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.

in Communications biology 2022

Adult gene reinstatement restores the learning and plasticity deficits of knockout mice.

Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.

White JJ, Bosman LWJ, Blot FGC, Osório C, Kuppens BW, Krijnen WHJJ, Andriessen C, De Zeeuw CI, Jaarsma D, Schonewille M
in Brain pathology (Zurich, Switzerland) 2021

Protein phosphatase 2B dual function facilitates synaptic integrity and motor learning.

Lin Z, Wu B, Paul MW, Li KW, Yao Y, Smal I, Onori MP, Hasanbegovic H, Bezstarosti K, Demmers J, Houtsmuller AB, Meijering E, Hoebeek FE, Schonewille M, Smit AB, Gao Z, De Zeeuw CI
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2021

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

Beekhof GC, Osório C, White JJ, van Zoomeren S, van der Stok H, Xiong B, Nettersheim IH, Mak WA, Runge M, Fiocchi FR, Boele HJ, Hoebeek FE, Schonewille M
in eLife 2021

NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.

Schonewille M, Girasole AE, Rostaing P, Mailhes-Hamon C, Ayon A, Nelson AB, Triller A, Casado M, De Zeeuw CI, Bouvier G
in Proceedings of the National Academy of Sciences of the United States of America 2021
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Vacancies

There are currently no vacancies on our lab.