lab

The development of cerebellar function and its role in sensorimotor integration

Lab Members

Martijn Schonewille
Dr. Martijn Schonewille (M)
Associate Professor
Lab Head
Catarina Osorio
Dr. Catarina Osorio
Postdoctoral Fellow
Joshua White
Dr. Joshua White
Postdoctoral Fellow
Friederike Stephani
Dr. Friederike Stephani
Postdoctoral Fellow
Hei Ling Lu
Hei Ling Lu
Phd Student
Gerco Beekhof
Mr. Gerco Beekhof
Phd Student
Hafsa Akaouche
Hafsa Akaouche
Master Student
Myrthe Griffioen
Myrthe Griffioen
Master Student
Iris van den Heuvel
Iris van den Heuvel
Master Student
Daniela Martin Machado
Daniela Martin Machado
Master Student
Laura Post
Laura Post
Research Technician

Recent Publications

Reply to Piochon et al.: NMDARs in Purkinje cells are not involved in parallel fiber-Purkinje cell synaptic plasticity or motor learning.

Schonewille M, Girasole AE, De Zeeuw CI, Bouvier G
in Proceedings of the National Academy of Sciences of the United States of America 2022

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022

Olivocerebellar control of movement symmetry.

Romano V, Zhai P, van der Horst A, Mazza R, Jacobs T, Bauer S, Wang X, White JJ, De Zeeuw CI
in Current biology : CB 2022

Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz.

Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.

White JJ, Bosman LWJ, Blot FGC, Osório C, Kuppens BW, Krijnen WHJJ, Andriessen C, De Zeeuw CI, Jaarsma D, Schonewille M
in Brain pathology (Zurich, Switzerland) 2021

Protein phosphatase 2B dual function facilitates synaptic integrity and motor learning.

Lin Z, Wu B, Paul MW, Li KW, Yao Y, Smal I, Onori MP, Hasanbegovic H, Bezstarosti K, Demmers J, Houtsmuller AB, Meijering E, Hoebeek FE, Schonewille M, Smit AB, Gao Z, De Zeeuw CI
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2021

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

Beekhof GC, Osório C, White JJ, van Zoomeren S, van der Stok H, Xiong B, Nettersheim IH, Mak WA, Runge M, Fiocchi FR, Boele HJ, Hoebeek FE, Schonewille M
in eLife 2021

NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.

Schonewille M, Girasole AE, Rostaing P, Mailhes-Hamon C, Ayon A, Nelson AB, Triller A, Casado M, De Zeeuw CI, Bouvier G
in Proceedings of the National Academy of Sciences of the United States of America 2021

Activity of Cerebellar Nuclei Neurons Correlates with ZebrinII Identity of Their Purkinje Cell Afferents.

Beekhof GC, Gornati SV, Canto CB, Libster AM, Schonewille M, De Zeeuw CI, Hoebeek FE
in Cells 2021

Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice

blot
in 2021

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration.

van’t Sant L.J., White J.J., Hoeijmakers J.H.J., Vermeij W.P., Jaarsma D.
in Acta neuropathologica communications 2021

AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.

Peter S, Urbanus BHA, Klaassen RV, Wu B, Boele HJ, Azizi S, Slotman JA, Houtsmuller AB, Schonewille M, Hoebeek FE, Spijker S, Smit AB, De Zeeuw CI
in Cell reports 2020

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.

Grasselli G, Boele HJ, Titley HK, Bradford N, van Beers L, Jay L, Beekhof GC, Busch SE, De Zeeuw CI, Schonewille M, Hansel C
in PLoS biology 2020

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells.

Wu B, Blot FG, Wong AB, Osório C, Adolfs Y, Pasterkamp RJ, Hartmann J, Becker EB, Boele HJ, De Zeeuw CI, Schonewille M
in eLife 2019

The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.

Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI
in The Journal of comparative neurology 2018
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Vacancies

There are currently no vacancies on our lab.