lab

Understanding the role of CAMK2 in neurodevelopment and neurodevelopmental disorders

Lab Members

Geeske van Woerden
Dr. Geeske van Woerden (GM)
Associate Professor
Lab Head
Pomme Rigter
Pomme Rigter
Phd Student
Charlotte de Konink
Charlotte de Konink
Research Technician
Selina Teurlings
Selina Teurlings
Research Technician

Recent Publications

TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development.

van Woerden GM, Bos M, de Konink C, Distel B, Trezza RA, Shur NE, Barañano K, Mahida S, Chassevent A, Schreiber A, Erwin AL, Gripp KW, Rehman F, Brulleman S, Mc Cormack R, de Geus G, Kalsner L, Sorlin A, Bruel AL, Koolen DA, Gabriel MK, Rossi M, Fitzpatrick DR, Wilkie AOM, Calpena E, Johnson D, Brooks A, van Slegtenhorst M, Fleischer J, Groepper D, Lindstrom K, Micheil Innes A, Goodwin A, Humberson J, Noyes A, Langley KG, Telegrafi A, Blevins A, Hoffman J, Guillen Sacoto MJ, Juusola J, Monaghan KG, Punj S, Simon M, Pfundt R, Elgersma Y, Kleefstra T
in Human mutation 2021

Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders.

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.

The Diagnostic Journey of a Patient with Prader-Willi-Like Syndrome and a Unique Homozygous Variant; Bio-Molecular Analysis and Review of the Literature.

Pellikaan K, van Woerden GM, Kleinendorst L, Rosenberg AGW, Horsthemke B, Grosser C, van Zutven LJCM, van Rossum EFC, van der Lely AJ, Resnick JL, Brüggenwirth HT, van Haelst MM, de Graaff LCG
in Genes 2021

Protein phosphatase 2B dual function facilitates synaptic integrity and motor learning.

Lin Z, Wu B, Paul MW, Li KW, Yao Y, Smal I, Onori MP, Hasanbegovic H, Bezstarosti K, Demmers J, Houtsmuller AB, Meijering E, Hoebeek FE, Schonewille M, Smit AB, Gao Z, De Zeeuw CI
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2021

CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles.

Moro A, van Woerden GM, Toonen RF, Verhage M
in PLoS biology 2020

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.

Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome.

in Nature neuroscience 2019

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes.

Sonzogni M, Hakonen J, Bernabé Kleijn M, Silva-Santos S, Judson MC, Philpot BD, van Woerden GM, Elgersma Y
in Molecular autism 2019

CAMK2-Dependent Signaling in Neurons Is Essential for Survival.

Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2019

Localization of Retinal Ca/Calmodulin-Dependent Kinase II-β (CaMKII-β) at Bipolar Cell Gap Junctions and Cross-Reactivity of a Monoclonal Anti-CaMKII-β Antibody With Connexin36.

Tetenborg S, Yadav SC, Brüggen B, Zoidl GR, Hormuzdi SG, Monyer H, van Woerden GM, Janssen-Bienhold U, Dedek K
in Frontiers in molecular neuroscience 2019

Measuring Electroencephalography: The Ups and Downs of Delta and Beta Bands as Biomarkers for 15q11-q13-Related Disorders.

The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

Tonazzini I, Van Woerden GM, Mientjes EJ, Elgersma Y, Cecchini M
in Mol Autism 2019

Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia

Heimer G, Van Woerden GM, Barel O, Marek-Yagel D, Kol N, Munting JB, Borghei M, Atawneh OM, Nissenkom A, Rechavi G, Anikster Y, Elgersma Y, Kushner SA, Ben Zeev B
in Hum Mutat 2019

The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

Vargas JY, Loria F, Wu YJ, Córdoba G, Nonaka T, Bellow S, Syan S, Hasegawa M, Van Woerden GM, Trollet C, Zurzolo C
in EMBO J 2019
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Vacancies

There are currently no vacancies on our lab.