Aleksandra Badura

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Dr. Aleksandra Badura

Biography

Pathological structure and function of the cerebellum is often found in people with autism, and cerebellar lesions at birth lead to a significant autism-risk. These observations brought me to investigate the role of the cerebellum in autism and conduct translational studies supported by Veni (2014) and Vidi (2018) grants. I have extensive expertise in systems neuroscience including working with disease mouse models. My laboratory works on unravelling the mechanism which underlie autism taking sex divergence into consideration. Recently, I have started a collaboration with the Department of Immunology to study the causal role of primary immunodeficiency in autism. My work is highly collaborative which is evident by my participation and leadership in (inter)national consortia (e.g. PIPgen MSCA-ITN network, SCANNER NWA-ORC-2022).

Education

2011

PhD in Neuroscience

in Erasmus University (the Netherlands)

2006

Masters Degree in Psychology

in Jagiellonian University (Poland)

Honors & Awards

2023

SCANNER project

NWA-ORC 2022 NWO grant

2021

PIPgen project

H2020 MSCA-ITN action

2020

MRACE Pilot

Erasmus MC

2019

Open Science Impulse

ZonMw

2018

Vidi NWO

ZonMw

2014

Veni NWO

ZonMw

2005

Erasmus Exchange Program

EU

Publications

1. Purkinje cell models: past, present and future

Fernández Santoro Elías Mateo , Karim Arun , Warnaar Pascal , De Zeeuw Chris I. , Badura Aleksandra , Negrello Mario
in Frontiers in Computational Neuroscience 2024
DOI: 10.3389/fncom.2024.1426653

2. Multiparametric Assays Capture Sex- and Environment-Dependent Modifiers of Behavioral Phenotypes in Autism Mouse Models.

Wahl L, Karim A, Hassett AR, van der Doe M, Dijkhuizen S, Badura A
in Biological psychiatry global open science 2024
DOI: 10.1016/j.bpsgos.2024.100366

3. Modeling and Inference of Sparse Neural Dynamic Functional Connectivity Networks Underlying Functional Ultrasound Data.

Ruben Wijnands, Justin Dauwels, Ines Serra, Pieter Kruizinga, Aleksandra Badura, Borbála Hunyadi
in 2023
DOI: 10.1109/ICASSPW59220.2023.10193029

4. Delay eyeblink conditioning performance and brain-wide c-Fos expression in male and female mice.

Oyaga MR, Serra I, Kurup D, Koekkoek SKE, Badura A
in Open biology 2023
DOI: 10.1098/rsob.220121

5. Cognitive-Affective Functions of the Cerebellum.

Rudolph S, Badura A, Lutzu S, Pathak SS, Thieme A, Verpeut JL, Wagner MJ, Yang YM, Fioravante D
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2023
DOI: 10.1523/JNEUROSCI.1451-23.2023

6. A novel automated approach for improving standardization of the marble burying test enables quantification of burying bouts and activity characteristics

Lucas Wahl, A. Mattijs Punt, Tara Arbab, Ingo Willuhn, Ype Elgersma, Aleksandra Badura
in eNeuro 2022
DOI: 10.1523/ENEURO.0446-21.2022

7. Measuring Cerebellar Processing and Sensorimotor Functions in Non-Human Primates

Nico A. Flierman, Eric Avila, Chris I. De Zeeuw, Aleksandra Badura
in 2022
DOI: 10.1007/978-1-0716-2026-7_14

8. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques.

Avila E, Flierman NA, Holland PJ, Roelfsema PR, Frens MA, Badura A, De Zeeuw CI
in Frontiers in cellular neuroscience 2022
DOI: 10.3389/fncel.2022.863181

9. Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022
DOI: 10.3389/fnmol.2022.831687

10. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, van der Zwaag W, Kreidl E, Zopf LM, Dalm VASH, Pel J, Gaiser C, van der Vliet R, Wahl L, Rietman A, Hill L, Leca I, Driessen G, Laffeber C, Brooks A, Katsikis PD, Lebbink JHG, Tachibana K, van der Burg M, De Zeeuw CI, Badura A, Busslinger M
in The Journal of experimental medicine 2022
DOI: 10.1084/jem.20220498
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