Aleksandra  Badura

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Dr. Aleksandra Badura

Biography

Throughout my Ph.D. studies and Postdoctoral Fellowships my work had focused on unraveling the function of the cerebellum in health and disease, encompassing two research lines: Line-1 integrated experimental techniques with modeling to investigate the mechanisms of cerebellar learning. I have established that the modulation of cerebellar activity is essential for motor learning and helped to develop a computer model that reproduces experimental data and can predict motor impairments based on neural activity. Using intravital two-photon imaging, we discovered that granule cells acquire signals predictive of motor performance . This marked a paradigm shift in the understanding of cerebellar coding. We are working on incorporating those findings into our model. Furthermore, I have developed tools for monitoring neuronal activity that advance two-photon imaging. In Line-2, I investigated the role of the cerebellum in autism spectrum disorder (ASD). We showed that cerebellar deficits are common in ASD. Recently, by disrupting cerebellar activity during different stages of development, we established a critical period during which specific cerebellar regions are crucial for non-motor behaviors. This work has been made possible by the VENI-ZonMw grant. In June 2018 I was awarded a VIDI-ZonMw grant to work on understanding the cerebello-cerebral networks underlying shared autistic traits.

Education

2011

PhD in Neuroscience

in Erasmus University (the Netherlands)

2006

Masters Degree in Psychology

in Jagiellonian University (Poland)

Honors & Awards

2021

PIPgen project

H2020 MSCA-ITN action

2020

MRACE Pilot

Erasmus MC

2019

Open Science Impulse

ZonMw

2018

Vidi NWO

ZonMw

2014

Veni NWO

ZonMw

2005

Erasmus Exchange Program

EU

Publications

1. Modeling and Inference of Sparse Neural Dynamic Functional Connectivity Networks Underlying Functional Ultrasound Data.

Ruben Wijnands, Justin Dauwels, Ines Serra, Pieter Kruizinga, Aleksandra Badura, Borbála Hunyadi
in 2023

2. Delay eyeblink conditioning performance and brain-wide c-Fos expression in male and female mice.

3. Cognitive-Affective Functions of the Cerebellum.

Rudolph S, Badura A, Lutzu S, Pathak SS, Thieme A, Verpeut JL, Wagner MJ, Yang YM, Fioravante D
in The Journal of neuroscience : the official journal of the Society for Neuroscience 2023

4. A novel automated approach for improving standardization of the marble burying test enables quantification of burying bouts and activity characteristics

Lucas Wahl, A. Mattijs Punt, Tara Arbab, Ingo Willuhn, Ype Elgersma, Aleksandra Badura
in eNeuro 2022

5. Measuring Cerebellar Processing and Sensorimotor Functions in Non-Human Primates

Nico A. Flierman, Eric Avila, Chris I. De Zeeuw, Aleksandra Badura
in 2022

6. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques.

Avila E, Flierman NA, Holland PJ, Roelfsema PR, Frens MA, Badura A, De Zeeuw CI
in Frontiers in cellular neuroscience 2022

7. Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022

8. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, van der Zwaag W, Kreidl E, Zopf LM, Dalm VASH, Pel J, Gaiser C, van der Vliet R, Wahl L, Rietman A, Hill L, Leca I, Driessen G, Laffeber C, Brooks A, Katsikis PD, Lebbink JHG, Tachibana K, van der Burg M, De Zeeuw CI, Badura A, Busslinger M
in The Journal of experimental medicine 2022

9. Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model.

Ines Serra, Olivia R. Manusama, Fabian.M.P. Kaiser, Izi Izumi Floriano, Lucas Wahl, Christian van der Zalm, Hanna IJspeert, P. Martin van Hagen, Nico J.M. van Beveren, Sandra M. Arend, Klaus Okkenhaug, Johan J.M. Pel, Virgil A.S.H. Dalm, Aleksandra Badura
in Brain, Behavior, & Immunity - Health 2021

10. Glissades Are Altered by Lesions to the Oculomotor Vermis but Not by Saccadic Adaptation

Flierman N.A., Ignashchenkova A., Negrello M., Their P., De Zeeuw C.I., Badura A.
in Frontiers in Behavioral Neuroscience 2019
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