lab

Mechanisms of neuronal degeneration in aging and disease

Lab Members

Dick Jaarsma
Dr. Dick Jaarsma (D.)
Assistant Professor
Lab Head
Maria Birkisdottir
Maria Birkisdottir
Phd Student
Lisanne van t Sant
Lisanne van t Sant
Phd Student
Christina Fevga
Christina Fevga
Master Student
Nienke Ramaker
Nienke Ramaker
Master Student

Recent Publications

The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.

Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI
in The Journal of comparative neurology 2018

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models.

Schreiber J, Grimbergen LA, Overwater I, van der Vaart MT, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y
in Scientific Reports 2017

Arc expression identifies the lateral amygdala fear memory trace

Gouty-Colomer, L. A., Hosseini, B., Marcelo, I. M., Schreiber, J., Slump, D. E., Yamaguchi, S., Houweling, A. R., Jaarsma, D., Elgersma, Y. and Kushner, S. A.
in Molecular Psychiatry 2016

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

Kuijpers, M., van de Willige, D., Freal, A., Chazeau, A., Franker, M. A., Hofenk, J., Rodrigues, R. J. C., Kapitein, L. C., Akhmanova, A., Jaarsma, D. and Hoogenraad, C. C.
in Neuron 2016

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M. and van der Eerden, B. C.
in Nature 2016

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.

Jaarsma D, Hoogenraad CC
in Frontiers in neuroscience 2015

Editorial on the honorary cerebellum issue for the retirement of Enrico Mugnaini.

De Zeeuw CI, Jaarsma D, Voogd J, Llinas R, Martina M
in Cerebellum (London, England) 2015

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency

Barnhoorn, S., Uittenboogaard, L. M., Jaarsma, D., Vermeij, W. P., Tresini, M., Weymaere, M., Menoni, H., Brandt, R. M. C., de Waard, M. C., Botter, S. M., Sarker, A. H., Jaspers, N. G. J., van der Horst, G. T. J., Cooper, P. K., Hoeijmakers, J. H. J. and van der Pluijm, I.
in PLoS Genetics 2014

A role for Bicaudal-D2 in radial cerebellar granule cell migration

Jaarsma, D., Van Den Berg, R., Wulf, P. S., Van Erp, S., Keijzer, N., Schlager, M. A., De Graaff, E., De Zeeuw, C. I., Jeroen Pasterkamp, R., Akhmanova, A. and Hoogenraad, C. C.
in Nature Communications 2014

Corrigendum: A role for Bicaudal-D2 in radial cerebellar granule cell migration

Jaarsma, D., Van Den Berg, R., Wulf, P. S., Van Erp, S., Keijzer, N., Schlager, M. A., De Graaff, E., De Zeeuw, C. I., Pasterkamp, R. J., Akhmanova, A. and Hoogenraad, C. C.
in Nature Communications 2014

Priming of microglia in a DNA-repair deficient model of accelerated aging

Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M. M., De Waard, M. C., Van der Pluijm, I., Brandt, R., Kreft, K. L., Laman, J. D., De Haan, G., Biber, K. P. H., Hoeijmakers, J. H. J., Eggen, B. J. L. and Boddeke, H. W. G. M.
in Neurobiology of Aging 2014

Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons

van Dis, V., Kuijpers, M., Haasdijk, E. D., Teuling, E., Oakes, S. A., Hoogenraad, C. C. and Jaarsma, D.
in Acta neuropathologica communications 2014

The Copper Metabolism MURR1 Domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner

Vonk, W. I. M., Kakkar, V., Bartuzi, P., Jaarsma, D., Berger, R., Hofker, M. H., Klomp, L. W. J., Wijmenga, C., Kampinga, H. H. and Van De Sluis, B.
in PLoS ONE 2014

Anatomical investigation of potential contacts between climbing fibers and cerebellar golgi cells in the mouse

Galliano, E., Baratella, M., Sgritta, M., Ruigrok, T. J. H., Haasdijk, E. D., Hoebeek, F. E., D'Angelo, E., Jaarsma, D., & De Zeeuw, C. I.
in Frontiers in Neural Circuits 2013

Cockayne syndrome pathogenesis: lessons from mouse models

Jaarsma, D., van der Pluijm, I., van der Horst, G. T., & Hoeijmakers, J. H.
in Mech Ageing Dev 2013
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Vacancies

There are currently no vacancies on our lab.