lab

Mechanisms of neuronal degeneration in aging and disease

Lab Members

Dick Jaarsma
Dr. Dick Jaarsma (D.)
Assistant Professor
Lab Head
Lisanne van t Sant
Lisanne van t Sant
Phd Student
Harry MacDonald
Harry MacDonald
Master Student
Cameron James Sawyer
Cameron James Sawyer
Master Student

Recent Publications

Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice.

Jaarsma D, Birkisdóttir MB, van Vossen R, Oomen DWGD, Akhiyat O, Vermeij WP, Koekkoek SKE, De Zeeuw CI, Bosman LWJ
in Neurobiology of disease 2024

Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health.

Birkisdóttir MB, Van't Sant LJ, Brandt RMC, Barnhoorn S, Hoeijmakers JHJ, Vermeij WP, Jaarsma D
in Frontiers in aging neuroscience 2023

Gene expression changes in cerebellum induced by dietary restriction.

Van't Sant LJ, Birkisdóttir MB, Ozinga RA, Gyenis Á, Hoeijmakers JHJ, Vermeij WP, Jaarsma D
in Frontiers in molecular neuroscience 2023

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

Birkisdóttir MB, van Galen I, Brandt RMC, Barnhoorn S, van Vliet N, van Dijk C, Nagarajah B, Imholz S, van Oostrom CT, Reiling E, Gyenis Á, Mastroberardino PG, Jaarsma D, van Steeg H, Hoeijmakers JHJ, Dollé MET, Vermeij WP
in Frontiers in aging 2022

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

Birkisdóttir MB, van Galen I, Brandt RMC, Barnhoorn S, van Vliet N, van Dijk C, Nagarajah B, Imholz S, van Oostrom CT, Reiling E, Gyenis Á, Mastroberardino PG, Jaarsma D, van Steeg H, Hoeijmakers JHJ, Dollé MET, Vermeij WP
in Frontiers in aging 2022

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice.

Birkisdóttir MB, Jaarsma D, Brandt RMC, Barnhoorn S, van Vliet N, Imholz S, van Oostrom CT, Nagarajah B, Portilla Fernández E, Roks AJM, Elgersma Y, van Steeg H, Ferreira JA, Pennings JLA, Hoeijmakers JHJ, Vermeij WP, Dollé MET
in Aging cell 2021

Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.

White JJ, Bosman LWJ, Blot FGC, Osório C, Kuppens BW, Krijnen WHJJ, Andriessen C, De Zeeuw CI, Jaarsma D, Schonewille M
in Brain pathology (Zurich, Switzerland) 2021

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration.

van’t Sant L.J., White J.J., Hoeijmakers J.H.J., Vermeij W.P., Jaarsma D.
in Acta neuropathologica communications 2021

Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation.

Tripathi P, Guo H, Dreser A, Yamoah A, Sechi A, Jesse CM, Katona I, Doukas P, Nikolin S, Ernst S, Aronica E, Glaß H, Hermann A, Steinbusch H, Feller AC, Bergmann M, Jaarsma D, Weis J, Goswami A
in Cell death & disease 2021

Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo.

Will L, Portegies S, van Schelt J, van Luyk M, Jaarsma D, Hoogenraad CC
in Acta neuropathologica communications 2019

The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.

Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI
in The Journal of comparative neurology 2018

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models.

Schreiber J, Grimbergen LA, Overwater I, van der Vaart MT, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y
in Scientific Reports 2017

Arc expression identifies the lateral amygdala fear memory trace

Gouty-Colomer, L. A., Hosseini, B., Marcelo, I. M., Schreiber, J., Slump, D. E., Yamaguchi, S., Houweling, A. R., Jaarsma, D., Elgersma, Y. and Kushner, S. A.
in Molecular Psychiatry 2016

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

Kuijpers, M., van de Willige, D., Freal, A., Chazeau, A., Franker, M. A., Hofenk, J., Rodrigues, R. J. C., Kapitein, L. C., Akhmanova, A., Jaarsma, D. and Hoogenraad, C. C.
in Neuron 2016

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M. and van der Eerden, B. C.
in Nature 2016
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Vacancies

There are currently no vacancies on our lab.