lab

Integrative neurobiology of psychiatric disorders

Lab Members

Steven Kushner
Prof.Dr. Steven Kushner (S.A.)
Full Professor
Lab Head
Femke de Vrij
Dr. Femke de Vrij
Assistant Professor
Guy Shpak
Guy Shpak
Postdoctoral Fellow
Christian Bouwkamp
Christian Bouwkamp
Postdoctoral Fellow
Bas Lendemeijer
Bas Lendemeijer
Phd Student
Shashini Munshi
Shashini Munshi
Phd Student
Giuseppe Cammarata
Giuseppe Cammarata
Master Student
Hilde Smeenk
Hilde Smeenk
Master Student
Denise Slump
Denise Slump
Research Technician
Mark van der Kroeg
Mark van der Kroeg
Research Technician

Recent Publications

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA
in Molecular psychiatry 2018

The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels.

Woodruff G, Bouwkamp CG, de Vrij FM, Lovenberg T, Bonaventure P, Kushner SA, Harrington AW
in Molecular pharmacology 2018

Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort.

Amin N, de Vrij FMS, Baghdadi M, Brouwer RWW, van Rooij JGJ, Jovanova O, Uitterlinden AG, Hofman A, Janssen HLA, Murad SD, Kraaij R, Stedehouder J, van den Hout MCGN, Kros JM, van IJcken WFJ, Tiemeier H, Kushner SA, van Duijn CM
in Molecular psychiatry 2018

Homozygous missense mutation associated with complicated hereditary spastic paraplegia

Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA
in Neurology. Genetics 2018

Activity-Dependent Myelination of Parvalbumin Interneurons Mediated by Axonal Morphological Plasticity.

in The Journal of neuroscience : the official journal of the Society for Neuroscience 2018

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.

García-León JA, Kumar M, Boon R, Chau D, One J, Wolfs E, Eggermont K, Berckmans P, Gunhanlar N, de Vrij F, Lendemeijer B, Pavie B, Corthout N, Kushner SA, Dávila JC, Lambrichts I, Hu WS, Verfaillie CM
in Stem cell reports 2018

Neuronal competition: microcircuit mechanisms define the sparsity of the engram.

Rao-Ruiz P, Yu J, Kushner SA, Josselyn SA
in Current opinion in neurobiology 2018

The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function

Proietti Onori M, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM
in Hum Mutat 2018

Maternal and paternal cannabis use during pregnancy and the risk of psychotic-like experiences in the offspring

Bolhuis K, Kushner SA, Yalniz S, Hillegers MHJ, Jaddoe VWV, Tiemeier H, El Marroun H
in Schizophrenia Research 2018

No evidence for an interaction between 5-HTTLPR genotype and early life adversity in cortisol responsivity to psychosocial stress in women.

Aleknaviciute J, Tulen JHM, de Rijke YB, van der Kroeg M, Kooiman CG, Kushner SA
in BJPsych Open 2018

Long term neurodevelopmental consequences of intrauterine exposure to lithium and antipsychotics: a systematic review and meta-analysis.

Poels EM, Schrijver L, Kamperman AM, Hillegers MH, Hoogendijk WJ, Kushner SA, Roza SJ
in European Child & Adolescent Psychiatry 2018

Psychotic-like experiences in pre-adolescence: what precedes the antecedent symptoms of severe mental illness?

Bolhuis K, Verhoeff ME, Blanken LM, Cibrev D, Jaddoe VWV, Verhulst FC, Hillegers MHJ, Kushner SA, Tiemeier H
in Acta Psychiatrica Scandinavica 2018

ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia.

Bouwkamp CG, Afawi Z, Fattal-Valevski A, Quadri M, Breedveld GJ, Masalha R, Mandel H, Abu Tailakh M, van Eijcken WF, Vernooij MW, Bonifati V, Kushner SA
in Neurology Genetics 2018

Single transcription factor based generation of oligodendrocytes from human pluripotent stem cells.

García-León JA, Kumar M, Boon R, Chau D, One J, Wolfs E, Eggermonts K, Berckmans P, Gunhanlar N, De Vrij FM, Pavie B, Corthout N, Kushner SA, Carlos J, Dávila C, Lambrichts I, Hu WS, Verfaillie CM
in Stem Cell Reports 2018

Are infectious agents involved in the pathogenesis of postpartum psychosis?

De Witte LD, Snijders G, Litjens M, Kamperman AM, Kushner SA, Kahn RS, Bergink V
in Journal of Affective Disorders 2018
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Vacancies

There are currently no vacancies on our lab.