lab

Circuit dynamics of temporal control

Lab Head: Devika-Narain

Lab Description

Losing the ability to precisely time movements can lead to debilitating disorders. Our research approaches this problem from three facets. First, we investigate how the brain exerts precise temporal control of behaviors under healthy conditions. Second, we develop neurotechnological tools that aid in restoring function in impaired states. Third, we study how humans and animals generate statistically optimal timing behaviors using probability theory, computational models and psychophysical techniques.

 

Our mechanistic questions are addressed using a combination of computational, behavioral, and neurophysiological techniques in rodents and humans. To study appropriate intervention technologies, we work in collaboration with clinicians, patients, and healthy human controls to characterize impairments in eliciting temporal behaviors. To study optimal timing, we use probabilistic theory and computational models to investigate how humans and rodents learn such timing behaviors.

 

We have several PhD and postdoc positions available. Please see the ‘vacancies’ section for a detailed job description. For further inquiries, please feel free to email Devika at d.narain@erasmusmc.nl.

Selected Publications

Heterogeneous encoding of temporal stimuli in the cerebellar cortex

De Zeeuw, C.*. Koppen, J.*, Bregman, G.G.B., Runge, M., & Narain, D.
in Nature Communications 2023
DOI: 10.1038/s41467-023-43139-9

Neural Implementations of Bayesian Inference

H. Sohn & D. Narain
in Current Opinion in Neurobiology 2021
DOI: https://doi.org/10.1016/j.conb.2021.09.008

Bayesian computations through latent cortical dynamics.

H. Sohn*, D. Narain * , N. Mierhaege* & M. Jazayeri
in Neuron 2019
DOI: 10.1016/j.neuron.2019.06.012

Flexible timing by temporal scaling of cortical responses.

J. Wang*, D. Narain * et al.
in Nature neuroscience 2018
DOI: 10.1038/s41593-017-0028-6

A cerebellar mechanism for learning prior distributions of time intervals.

D. Narain, E.D. Remington, C.I. De Zeeuw, & M. Jazayeri
in Nature Communications 2018
DOI: 10.1038/s41467-017-02516-x

Lab Members

Devika Narain
Dr. ir. Devika Narain (D.)
Associate Professor
Lab Head
Julius Koppen
Julius Koppen
Phd Student
Zhuoshi Liu
Zhuoshi Liu
Phd Student
Luca Mangili
Luca Mangili
Phd Student
Ilse Klinkhamer
Ilse Klinkhamer
Master Student
Charlotte Wissing
Charlotte Wissing
Master Student
Bas Nieuwenhuis
Bas Nieuwenhuis
Master Student
Niek Rijnders
Niek Rijnders
Master Student
Lies Piree
Lies Piree
Sascha Bruggen van
Sascha Bruggen van
Eline Levering
Eline Levering
Bachelor Student
Marit Runge
Marit Runge
Research Technician

Selected Publications

Heterogeneous encoding of temporal stimuli in the cerebellar cortex

De Zeeuw, C.*. Koppen, J.*, Bregman, G.G.B., Runge, M., & Narain, D.
in Nature Communications 2023
DOI: 10.1038/s41467-023-43139-9

Neural Implementations of Bayesian Inference

H. Sohn & D. Narain
in Current Opinion in Neurobiology 2021
DOI: https://doi.org/10.1016/j.conb.2021.09.008

Bayesian computations through latent cortical dynamics.

H. Sohn*, D. Narain * , N. Mierhaege* & M. Jazayeri
in Neuron 2019
DOI: 10.1016/j.neuron.2019.06.012

Flexible timing by temporal scaling of cortical responses.

J. Wang*, D. Narain * et al.
in Nature neuroscience 2018
DOI: 10.1038/s41593-017-0028-6

A cerebellar mechanism for learning prior distributions of time intervals.

D. Narain, E.D. Remington, C.I. De Zeeuw, & M. Jazayeri
in Nature Communications 2018
DOI: 10.1038/s41467-017-02516-x

Recent Publications

Disynaptic inhibitory cerebellar control over caudal medial accessory olive.

van Hoogstraten WS, Lute MCC, Liu Z, Broersen R, Mangili L, Kros L, Gao Z, Wang X, van den Maagdenberg AMJM, De Zeeuw CI
in eNeuro 2024
DOI: 10.1523/ENEURO.0262-23.2023

Heterogeneous encoding of temporal stimuli in the cerebellar cortex

De Zeeuw, C.*. Koppen, J.*, Bregman, G.G.B., Runge, M., & Narain, D.
in Nature Communications 2023
DOI: 10.1038/s41467-023-43139-9

Neural Implementations of Bayesian Inference

H. Sohn & D. Narain
in Current Opinion in Neurobiology 2021
DOI: https://doi.org/10.1016/j.conb.2021.09.008

NeuroGym: An open resource for developing and sharing neuroscience tasks

Manuel Molano-Mazon, Joao Barbosa, Jordi Pastor-Ciurana, Marta Fradera, Ru-yuan Zhang, Jeremy Forest, Jorge del Pozo Lerida, Li Ji-An, Christopher J Cueva, Jaime de la Rocha, Devika Narain, Guangyu Robert Yang
in 2021
DOI: 10.31234/osf.io/aqc9n

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

Beekhof GC, Osório C, White JJ, van Zoomeren S, van der Stok H, Xiong B, Nettersheim IH, Mak WA, Runge M, Fiocchi FR, Boele HJ, Hoebeek FE, Schonewille M
in eLife 2021
DOI: 10.7554/eLife.63668

Bayesian computations through latent cortical dynamics.

H. Sohn*, D. Narain * , N. Mierhaege* & M. Jazayeri
in Neuron 2019
DOI: 10.1016/j.neuron.2019.06.012

Flexible timing by temporal scaling of cortical responses.

J. Wang*, D. Narain * et al.
in Nature neuroscience 2018
DOI: 10.1038/s41593-017-0028-6

A dynamical systems perspective on flexible motor timing.

E.D. Remington*, S.W. Egger*, D. Narain, J. Wang & M. Jazayeri
in Trends in Cognitive Science 2018
DOI: 10.1016/j.tics.2018.07.010

Flexible sensorimotor computations through rapid reconfiguration of cortical dynamics.

E.D. Remington, D. Narain, E.A. Hosseini, and M. Jazayeri
in Neuron 2018
DOI: 10.1016/j.neuron.2018.05.020

A cerebellar mechanism for learning prior distributions of time intervals.

D. Narain, E.D. Remington, C.I. De Zeeuw, & M. Jazayeri
in Nature Communications 2018
DOI: 10.1038/s41467-017-02516-x
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Alumni

# Name Job Description Current Position
1 Francesca Fiocchi | PhD student | postdoctoral associate, WashU Medicine, Dept. of Psychiatry -

Vacancies

There are currently no vacancies on our lab.