Cerebro-cerebellar Communication

The brain exhibits extraordinary capabilities in receiving a wide range of sensory inputs from our environment and translating them into precise motor actions. This process, known as sensorimotor processing, is pivotal not only for controlling movement but also plays a crucial role in advanced executive and cognitive functions. Effective sensorimotor processing requires cooperation among various brain regions. While there has been considerable research elucidating the specific cellular and circuitry mechanisms underpinning sensorimotor processing in these areas, how these regions compute and coordinate collectively are still largely enigmatic.

In pursuit of deeper insights, our research focuses on the inter-regional communication within the brain during various sensorimotor behaviors. We employ a multifaceted approach, integrating anatomical studies, behavioral analyses, pharmacological interventions, optogenetic techniques, electrophysiological and optical investigations. The primary objective of this effort is to delineate both the anatomical and functional architecture of the interconnected modules involved in sensorimotor learning and in the execution of natural behaviors. Through our work, we aim to shed light on the complex interplay of brain regions that enables the remarkable sensorimotor capabilities of the brain.