Laurens  Bosman

contact

  • l.bosman@erasmusmc.nl
  • +31 010 7043358
  • Room: Ee-1208
  • Dr. Molewaterplein 40, Faculty Building, Rotterdam, The Netherlands

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Dr. Laurens Bosman (L.W.J.)

Biography

Laurens Bosman studied biology / biophysics at Leiden University and obtained his PhD in membrane physiology at the Vrije Universiteit Amsterdam. As post-doctoral fellow, he worked together with Arthur Konnerth at the Ludwig-Maximilians-Universität and the Techische Universität München. Currently, he works as assistant professor at the Department of Neuroscience of the Erasmus MC, chaired by Chris De Zeeuw. His research interests slowly drifted from circuit development in the cerebellum, with a special interest in developmental climbing fiber synapse elimination, to the use of the cerebellar circuitry during behaviour. He is particularly interested in how the cerebellum uses sensory feedback to adapt motor behaviour in health and disease.

Research Interests

  1. Sensorimotor integration in the cerebellum
  2. Rodent whisker system
  3. Control of respiration
  4. Spinocerebellar ataxia
  5. Climbing fiber development

Education

MSc in Biology (cum laude), Rijksuniversiteit Leiden, Leiden, The Netherlands; PhD in Earth and Life Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (promoter: prof. Arjen Brussaard)

Publications

1. Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior.

Lindeman S, Hong S, Kros L, Mejias JF, Romano V, Oostenveld R, Negrello M, Bosman LWJ, De Zeeuw CI
in Proceedings of the National Academy of Sciences of the United States of America 2021

2. Inducible expression of human C9ORF72 36x G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

F.W. Riemslagh, E.C. van der Toorn, R.F.M. Verhagen, A. Maas, L.W.J. Bosman, R.K. Hukema, R. Willemsen
in Disease Models & Mechanisms 2021

3. Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.

White JJ, Bosman LWJ, Blot FGC, Osório C, Kuppens BW, Krijnen WHJJ, Andriessen C, De Zeeuw CI, Jaarsma D, Schonewille M
in Brain pathology (Zurich, Switzerland) 2021

4. Stairway to Abstraction - an Iterative Algorithm for Whisker Detection in Video Frames.

in 2020 IEEE 11th Latin American Symposium on Circuits Systems (LASCAS) 2020

5. Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

L.W.J. Bosman, S.N. Haify, R.S.D. Mankoe, V. Boumeester, E.C. van der Toorn, R.F.M. Verhagen, R. Willemsen, R.K. Hukema
in Frontiers in Molecular Biosciences 2020

6. Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum.

Romano V, Reddington AL, Cazzanelli S, Mazza R, Ma Y, Strydis C, Negrello M, Bosman LWJ, De Zeeuw CI
in Cell reports 2020

7. WhiskEras: A New Algorithm for Accurate Whisker Tracking.

in Frontiers in cellular neuroscience 2020

8. Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates.

Haify SN, Mankoe RSD, Boumeester V, van der Toorn EC, Verhagen RFM, Willemsen R, Hukema RK, Bosman LWJ
in Frontiers in molecular biosciences 2020

9. Quasiperiodic rhythms of the inferior olive.

Negrello M, Warnaar P, Romano V, Owens CB, Lindeman S, Iavarone E, Spanke JK, Bosman LWJ, De Zeeuw CI
in PLoS computational biology 2019

10. Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control.

Ju C, Bosman LWJ, Hoogland TM, Velauthapillai A, Murugesan P, Warnaar P, van Genderen RM, Negrello M, De Zeeuw CI
in The Journal of physiology 2019
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