lab

BrainEcho Lab

Lab Head: Pieter-Kruizinga

Lab Description

BrainEcho Lab: Advancing Ultrasound Imaging for the Brain

 

At the BrainEcho Lab we develop ultrasound imaging techniques for the brain. Our goal is to provide neuroscientists and neurosurgeons with advanced imaging tools that enhance the understanding of brain processes and improve the precision of brain treatments.

 

We specialize in imaging brain hemodynamics, which serve as a proxy for neural activity. This technique, known as functional ultrasound imaging (fUS or fUSi), is applied in both fundamental brain research and practical neurosurgical settings, playing a crucial role in improving brain tumor resections.

 

Our approach focuses on computational ultrasound imaging (cUSi), a new method that uses complex ultrasound fields, simple hardware and a physical wave prediction model. This enables us to generate high-resolution, multi-dimensional images of the brain.

 

In addition to advancing ultrasound imaging, we are dedicated to enhancing neurosurgical procedures by integrating and developing new technologies for the operating room, ultimately aiming to improve patient outcomes and surgical precision.

 

 

Lab Members

Pieter Kruizinga
Dr. Pieter Kruizinga (P.)
Assistant Professor
Lab Head
Jason Voorneveld
Dr. ir. Jason Voorneveld
Assistant Professor
Sadaf Soloukey
Sadaf Soloukey
Postdoctoral Fellow
Luuk Verhoef
Luuk Verhoef
Phd Student
Emma Gommers
Emma Gommers
Master Student
Cindy Steward
Cindy Steward
Master Student
Michael Brown
Michael Brown
Scientific Researcher
Georgios Pilikos
Georgios Pilikos
Florescu Stefanos
Florescu Stefanos
Research Technician
Frits Mastik
Frits Mastik
Scientific Researcher
Lucy Wei
Dr. Lucy Wei
Scientific Researcher
Jan de Jong
Jan de Jong
Scientific Researcher
Erol Aybuke
Erol Aybuke
Scientific Researcher

Recent Publications

The Road to a Realistic 3D Model for Estimating R and R* Relaxation Versus Gd-DTPA Concentration in Whole Blood and Brain Tumor Vasculature.

van Dorth D, Alafandi A, Soloukey S, Kruizinga P, Venugopal K, Delphin A, Poot DHJ, Christen T, Smits M, de Bresser J, Hernandez-Tamames JA, van Osch MJP
in NMR in biomedicine 2025
DOI: 10.1002/nbm.5308

Patient-Specific Vascular Flow Phantom for MRI- and Doppler Ultrasound Imaging.

Soloukey S, Generowicz B, Warnert E, Springeling G, Schouten J, De Zeeuw C, Dirven C, Vincent A, Kruizinga P
in Ultrasound in medicine & biology 2024
DOI: 10.1016/j.ultrasmedbio.2024.02.010

Four-dimensional computational ultrasound imaging of brain hemodynamics.

Brown MD, Generowicz BS, Dijkhuizen S, Koekkoek SKE, Strydis C, Bosch JG, Arvanitis P, Springeling G, Leus GJT, De Zeeuw CI, Kruizinga P
in Science advances 2024
DOI: 10.1126/sciadv.adk7957

Probing the glioma microvasculature: a case series of the comparison between perfusion MRI and intraoperative high-frame-rate ultrafast Doppler ultrasound.

Alafandi A, Tbalvandany SS, Arzanforoosh F, van Der Voort SR, Incekara F, Verhoef L, Warnert EAH, Kruizinga P, Smits M
in European radiology experimental 2024
DOI: 10.1186/s41747-023-00406-0

Functional imaging of the exposed brain

Soloukey Sadaf, Vincent Arnaud J. P. E., Smits Marion, De Zeeuw Chris I., Koekkoek Sebastiaan K. E., Dirven Clemens M. F., Kruizinga Pieter
in Frontiers in Neuroscience 2023
DOI: 10.3389/fnins.2023.1087912

Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma.

Soloukey S, Verhoef L, Generowicz BS, De Zeeuw CI, Koekkoek SKE, Vincent AJPE, Dirven CMF, Harhangi BS, Kruizinga P
in Frontiers in surgery 2023
DOI: 10.3389/fsurg.2023.1153605

Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study

S. Soloukey, E. Collée, L. Verhoef, D.D. Satoer, C.M.F. Dirven, E.M. Bos, J.W. Schouten, B.S. Generowicz, F. Mastik, C.I. De Zeeuw, S.K.E. Koekkoek, A.J.P.E. Vincent, M. Smits, P. Kruizinga
in NeuroImage 2023
DOI: 10.1016/j.neuroimage.2023.120435

Modeling and Inference of Sparse Neural Dynamic Functional Connectivity Networks Underlying Functional Ultrasound Data.

Ruben Wijnands, Justin Dauwels, Ines Serra, Pieter Kruizinga, Aleksandra Badura, Borbála Hunyadi
in 2023
DOI: 10.1109/ICASSPW59220.2023.10193029

GLM-Regularized Low-Rank Factorization For Extracting Functional Response From Swept-3D Functional Ultrasound.

Aybüke Erol, Bastian Generowicz, Pieter Kruizinga, Borbála Hunyadi
in 2023
DOI: 10.1109/ICASSPW59220.2023.10193574

Ultrasonic Imaging Through Aberrating Layers Using Covariance Matching.

Pim van der Meulen, Mario Coutiño, Johannes G. Bosch, Pieter Kruizinga, Geert Leus
in IEEE Trans. Computational Imaging 2023
DOI: 10.1109/TCI.2023.3302233

High-resolution micro-Doppler imaging during neurosurgical resection of an arteriovenous malformation: illustrative case

Soloukey, S., Verhoef, L., Jan van Doormaal, P., Generowicz, B. S., Dirven, C. M. F., De Zeeuw, C. I., Koekkoek, S. K. E., Kruizinga, P., Vincent, A. J. P. E., & Schouten, J. W.
in Journal Of Neurosurgery 2022
DOI: 10.3171/CASE22177

Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09613-3

Correction to: Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09619-x

How to Identify Responders and Nonresponders to Dorsal Root Ganglion-Stimulation Aimed at Eliciting Motor Responses in Chronic Spinal Cord Injury: Post Hoc Clinical and Neurophysiological Tests in a Case Series of Five Patients.

Soloukey S, Drenthen J, Osterthun R, de Vos CC, De Zeeuw CI, Huygen FJPM, Harhangi BS
in Neuromodulation : journal of the International Neuromodulation Society 2021
DOI: 10.1111/ner.13379

Dorsal Root Ganglion (DRG) Versatile Stimulator Prototype Developed for Use in Locomotion Recovery Early Clinical Trials.

Konstantina Kolovou-Kouri, Sadaf Soloukey, Frank J. P. M. Huygen, Biswadjiet S. Harhangi, Wouter A. Serdijn, Vasiliki Giagka
in 2021
DOI: 10.1109/NER49283.2021.9441101
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Vacancies

PhD position on Four-dimensional ultrasound imaging of the brain

BrainEcho Lab · Rotterdam, the Netherlands

Join us to pioneer 4D ultrasound imaging tech! Develop real-time 4D ultrasound imaging, and integrate AI to assess & monitor brain vasculature. Interested Postdocs are also encouraged to apply.If you are interested in applying, please apply here...

  • Full Time
  • DATE POSTED: 07 Mar 2025