Ype  Elgersma

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Prof.Dr. Ype Elgersma (Y)

Publications

1. A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides.

Smeenk H, Lendemeijer B, Buurma MG, Forgione MA, Slump DE, Monshouwer RA, Wallaard I, Mientjes EJ, Hoogendijk WJG, Elgersma Y, de Vrij FMS, Kushner SA
in Scientific reports 2026

2. Phosphoproteomic Analysis of Cortical Tissue from Mice Lacking Both CaMKIIα and CaMKIIβ Identifies Novel In Vivo Substrates.

Rigter PMF, Bezstarosti K, Koc OC, Perfitt TL, Demmers JAA, Colbran RJ, Stratton MM, Elgersma Y, van Woerden GM
in ACS chemical neuroscience 2026

3. UBE3A isoform-selective and non-selective contributions to Angelman syndrome phenotypes.

Krzeski JC, Mientjes EJ, Judson MC, Dong G, Hipp RI, Lien KH, Gu B, Philpot BD, Elgersma Y
in Molecular psychiatry 2026

4. Crossing the finish line towards a disease-modifying treatment for Angelman syndrome.

Judson MC, de Almeida LP, Burdine RD, Chamberlain SJ, Deverman BE, Distel B, Ehlers MD, Jalazo E, Kushner SA, Nespeca M, Sanders SJ, Scheffner M, Yi JJ, Zylka MJ, Elgersma Y, Philpot BD
in Journal of neurodevelopmental disorders 2026

5. Navigating Human Astrocyte Differentiation: Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development.

Schuurmans IME, Mordelt A, Guevara-Ferrer M, Linda K, Duineveld D, Puvogel S, Hommersom MP, Scheefhals N, Rahm L, Dyke E, Scholten GJ, Knorz C, Jimenez CG, van Egmond N, Oudakker A, Bijnagte-Schoenmaker C, van Bokhoven H, Wei W, Hofmann S, Jung-Klawitter S, Mojica-Perez S, Parent J, Carotenuto L, Weckhuysen S, Maas N, Elgersma Y, van de Ven E, Lefeber D, Lygeroudi A, de Vries HE, Jordi L, Polymenidou M, Mitchell-Garcia T, Dragan I, Dolga A, de Witte LD, van Karnebeek CDM, Ellis J, Garanto A, Nadif Kasri N
in Glia 2026

6. Variants in TREX complex subunits (THOC2, ALYREF, THOC6, THOC7) define a neurodevelopmental disability spectrum.

Kumar R, Gardner A, Bhattacharjee R, Agarwala S, van Eyk CL, Corbett MA, Carroll R, Kroes T, Ritchie T, de Nys R, Mazurkiewicz D, Bing W, Palmer EE, Field M, Verseput JJA, de Vries BBA, Dingemans AJM, Zhang Q, Li F, Bernier F, Lauzon J, Śmigiel R, Ortigoza-Escobar JD, García-Cazorla A, Darling A, Boerkoel CF, Huynh S, Costain G, van Ham TJ, Kasteleijn E, van Slegtenhorst M, Barakat TS, Elgersma Y, van Ierland Y, Veenma D, Azmanov D, Weisman AG, Prada CE, Parkash S, Rideout AL, Kerstjens-Frederikse WS, Vengoechea J, Schoene-Bake JC, Devillard F, van der Smagt J, Giesbertz NAA, Fry AE, Jezkova J, Kampmeier A, Kuechler A, Grasshoff U, Bertrand M, Hickey SE, Hunter JM, Marr MV, Dupont J, Bigoni S, Ferlini A, Selvatici R, Chatron N, Lesca G, Januel L, Rossi M, Rogers C, Davis JM, McKenzie F, Marbach F, Gieldon L, Schmidt WM, Paquay A, Bittner RE, Mahal S, Bernert G, Sinnerbrink I, Goodwin L, Cooper S, Bannink N, Jolly LA, McGaughran J, Bosman A, Hernan R, Chung WK, Valenzuela I, Cuscó I, Schlüter A, Pujol A, Pérez-Jurado LA, Gecz J
in Genetics in medicine : official journal of the American College of Medical Genetics 2026

7. The effect of lamotrigine on cortical inhibition and plasticity in Neurofibromatosis type 1: Exploratory analysis of a randomized controlled trial (NF1-EXCEL).

Ottenhoff MJ, Heuvelmans A, Castricum J, Tulen JH, Rens G, Fujiyama H, Levin O, Swinnen SP, Moll HA, Wit MY, Elgersma Y
in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2025

8. UBE3A reinstatement restores behaviorand proteome in an Angelman syndrome mouse model of imprinting defects.

Milazzo C, Narayanan R, Badillo S, Wang S, Almand R, Monshouwer R, Tzouros M, Golling S, Mientjes E, Chamberlain S, Kremer T, Elgersma Y
in Molecular autism 2025

9. Localization of human UBE3A isoform 3 is highly sensitive to amino acid substitutions at p.Met21 position.

van Esbroeck ACM, Verhagen RFM, Biagioni M, Fossati M, Distel B, Elgersma Y
in Human molecular genetics 2025

10. Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.

Küry S, Stanton JE, van Woerden GM, Bosc-Rosati A, Hsieh TC, Bray L, Oloudé M, Rosenfelt C, Scott-Boyer MP, Most V, Wang T, Papendorf JJ, de Konink C, Deb W, Vignard V, Studencka-Turski M, Besnard T, Hajdukowicz AM, Thiel FG, Wolfgramm S, Florenceau L, Cuinat S, Marsac S, Verrès Y, Dangoumau A, Poirier L, Wentzensen IM, Tuttle A, Forster C, Striesow J, Golnik R, Ortiz D, Jenkins L, Rosenfeld JA, Ziegler A, Houdayer C, Bonneau D, Torti E, Begtrup A, Monaghan KG, Mullegama SV, Volker-Touw CMLN, van Gassen KLI, Oegema R, de Pagter MS, Steindl K, Rauch A, Ivanovski I, McDonald K, Boothe E, Dauber A, Baker J, Fabie NAV, Bernier RA, Turner TN, Srivastava S, Dies KA, Swanson LC, Costin C, Abdulrazak A, Jobling RK, Pappas J, Rabin R, Niyazov D, Chun-Hui Tsai A, Kovak K, Beck DB, Malicdan MCV, Adams DR, Wolfe L, Ganetzky RD, Muraresku CC, Babikyan D, Sedláček Z, Hančárová M, Timberlake AT, Saif HA, Nestler B, King K, Hajianpour MJ, Costain G, Prendergast D, Li C, Geneviève D, Vitobello A, Sorlin A, Philippe C, Harel T, Toker O, Sabir A, Lim D, Hamilton MJ, Bryson LJ, Cleary E, Weber S, Hoffman TL, Cueto-González AM, Tizzano EF, Gómez-Andrés D, Codina-Solà M, Ververi A, Pavlidou E, Lambropoulos A, Garganis K, Rio M, Levy J, Langas SJ, McRae AM, Lessard MK, D
in Nature communications 2025
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