lab

Neural networks underlying behavioral flexibility

Lab Members

Aleksandra Badura
Dr. Aleksandra Badura
Associate Professor
Lab Head
Ines Serra
Dr. Ines Serra
Postdoctoral Fellow
Lucas Wahl
Lucas Wahl
Phd Student
Devika Kurup
Devika Kurup
Phd Student
Alessandra De Amici
Alessandra De Amici
Master Student
Yue Zhao
Yue Zhao
Master Student
Arun Karim
Arun Karim
Master Student
Maria Roa Oyaga
Maria Roa Oyaga
Research Assistant
Shu Harskamp
Shu Harskamp
Bachelor Student
Roxanne ter Haar
Roxanne ter Haar
Research Technician

Selected Publications

A novel automated approach for improving standardization of the marble burying test enables quantification of burying bouts and activity characteristics

Lucas Wahl, A. Mattijs Punt, Tara Arbab, Ingo Willuhn, Ype Elgersma, Aleksandra Badura
in eNeuro 2022

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022

Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, van der Zwaag W, Kreidl E, Zopf LM, Dalm VASH, Pel J, Gaiser C, van der Vliet R, Wahl L, Rietman A, Hill L, Leca I, Driessen G, Laffeber C, Brooks A, Katsikis PD, Lebbink JHG, Tachibana K, van der Burg M, De Zeeuw CI, Badura A, Busslinger M
in The Journal of experimental medicine 2022

Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model.

Ines Serra, Olivia R. Manusama, Fabian.M.P. Kaiser, Izi Izumi Floriano, Lucas Wahl, Christian van der Zalm, Hanna IJspeert, P. Martin van Hagen, Nico J.M. van Beveren, Sandra M. Arend, Klaus Okkenhaug, Johan J.M. Pel, Virgil A.S.H. Dalm, Aleksandra Badura
in Brain, Behavior, & Immunity - Health 2021

Normal cognitive and social development require posterior cerebellar activity

Badura A., Verpeut J.L., Metzger J.W, Pereira T.D, Pisano T.J., Deverett B., Bakshinskaya D.E., Wang S.S.-H
in eLife 2018

Recent Publications

Measuring Cerebellar Processing and Sensorimotor Functions in Non-Human Primates

Nico A. Flierman, Eric Avila, Chris I. De Zeeuw, Aleksandra Badura
in 2022

A novel automated approach for improving standardization of the marble burying test enables quantification of burying bouts and activity characteristics

Lucas Wahl, A. Mattijs Punt, Tara Arbab, Ingo Willuhn, Ype Elgersma, Aleksandra Badura
in eNeuro 2022

Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques.

Avila E, Flierman NA, Holland PJ, Roelfsema PR, Frens MA, Badura A, De Zeeuw CI
in Frontiers in cellular neuroscience 2022

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, and Aleksandra Badura
in Front Mol Neurosci. 2022

Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder.

Kaiser FMP, Gruenbacher S, Oyaga MR, Nio E, Jaritz M, Sun Q, van der Zwaag W, Kreidl E, Zopf LM, Dalm VASH, Pel J, Gaiser C, van der Vliet R, Wahl L, Rietman A, Hill L, Leca I, Driessen G, Laffeber C, Brooks A, Katsikis PD, Lebbink JHG, Tachibana K, van der Burg M, De Zeeuw CI, Badura A, Busslinger M
in The Journal of experimental medicine 2022

Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model.

Ines Serra, Olivia R. Manusama, Fabian.M.P. Kaiser, Izi Izumi Floriano, Lucas Wahl, Christian van der Zalm, Hanna IJspeert, P. Martin van Hagen, Nico J.M. van Beveren, Sandra M. Arend, Klaus Okkenhaug, Johan J.M. Pel, Virgil A.S.H. Dalm, Aleksandra Badura
in Brain, Behavior, & Immunity - Health 2021

Glissades Are Altered by Lesions to the Oculomotor Vermis but Not by Saccadic Adaptation

Flierman N.A., Ignashchenkova A., Negrello M., Their P., De Zeeuw C.I., Badura A.
in Frontiers in Behavioral Neuroscience 2019

Normal cognitive and social development require posterior cerebellar activity

Badura A., Verpeut J.L., Metzger J.W, Pereira T.D, Pisano T.J., Deverett B., Bakshinskaya D.E., Wang S.S.-H
in eLife 2018

Cerebellar Granule Cells: Dense, Rich and Evolving Representations.

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

Giovannucci A, Badura A, Deverett B, Najafi F, Pereira TD, Gao Z, Ozden I, Kloth AD, Pnevmatikakis E, Paninski L, De Zeeuw CI, Medina JF, Wang SS
in Nature neuroscience 2017

Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.

in Scientific reports 2016

A cerebellar learning model of Vestibulo-Ocular Reflex adaptation in wild-type and mutant mice

Clopath, C., Badura, A., De Zeeuw, C. I. and Brunel, N.
in Journal of Neuroscience 2014

Climbing fiber input shapes reciprocity of Purkinje cell firing.

Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI
in Neuron 2013

Climbing fiber input shapes reciprocity of purkinje cell firing

Badura, A., Schonewille, M., Voges, K., Galliano, E., Renier, N., Gao, Z., Witter, L., Hoebeek, F., Chédotal, A., & DeZeeuw, C. I.
in Neuron 2013

Raising Cytosolic Cl - in Cerebellar Granule Cells Affects Their Excitability and Vestibulo-Ocular Learning

Seja, P., M. Schonewille, G. Spitzmaul, A. Badura, I. Klein, Y. Rudhard, W. Wisden, C. A. Hübner, C. I. De Zeeuw, and T. J. Jentsch
in EMBO Journal 2012
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Alumni

# Name Job Description Current Position
1 Nynke Hettema Master student PhD student at TU Delft
2 Enzo Nio Master student PhD student at Klinik für Neurologie Universitätsklinikum Essen
3 Irina Scheer Master student PhD student at University of Fribourg
4 Amy Hassett Master student PhD student at UCD School of Medicine
5 Saffira Tjon Master student PhD student at Okinawa Institute Of Science and Technology
6 Yawende Landbrug Master student Application Specialist at Artinis Medical Systems

Vacancies

There are currently no vacancies on our lab.