lab

Associative learning

Lab Head: Sebastiaan-Koekkoek

Lab Description







Associative learning is a broad category that includes many of our daily learning activities that involve the formation of associations among stimuli and/or responses. Classical (or Pavlovian) conditioning   is one of the forms of associative learning and is induced by a procedure in which a generally neutral stimulus is paired with a stimulus that generally elicits a response. Our lab evolved around this simple learning task.

We generally use eyeblink conditioning procedures  to study all aspects of associative learning but over the years we have continuously developed  new methods to broaden the scientific toolkit we can employ to understand this behavior. This development endeavor over time has led to a substantial engineering division in the lab consisting of electrical as well as computer engineers and scientists. 

Since 2019, together with Pieter Kruizinga and Christos Strydis (Head of the Neurocomputing Lab) we have started CUBE, a multidisciplinary center where we develop functional ultrasound into a new brain imaging method that will help us in getting the bigger picture of the awake behaving brain in both mice as well as humans.

Lab Members

Sebastiaan Koekkoek
Dr. Sebastiaan Koekkoek (SK)
Assistant Professor
Lab Head
Nina Oude de
Nina Oude de
Scientific Researcher

Recent Publications

Acute aerobic exercise enhances associative learning in regular exercisers but not in non-regular exercisers.

Gultig KD, Boele CP, Roggeveen LEM, Soong TF, Koekkoek SKE, De Zeeuw CI, Boele HJ
in Frontiers in behavioral neuroscience 2025
DOI: 10.3389/fnbeh.2024.1515682

Four-dimensional computational ultrasound imaging of brain hemodynamics.

Brown MD, Generowicz BS, Dijkhuizen S, Koekkoek SKE, Strydis C, Bosch JG, Arvanitis P, Springeling G, Leus GJT, De Zeeuw CI, Kruizinga P
in Science advances 2024
DOI: 10.1126/sciadv.adk7957

Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice.

Jaarsma D, Birkisdóttir MB, van Vossen R, Oomen DWGD, Akhiyat O, Vermeij WP, Koekkoek SKE, De Zeeuw CI, Bosman LWJ
in Neurobiology of disease 2024
DOI: 10.1016/j.nbd.2024.106422

Functional imaging of the exposed brain

Soloukey Sadaf, Vincent Arnaud J. P. E., Smits Marion, De Zeeuw Chris I., Koekkoek Sebastiaan K. E., Dirven Clemens M. F., Kruizinga Pieter
in Frontiers in Neuroscience 2023
DOI: 10.3389/fnins.2023.1087912

Delay eyeblink conditioning performance and brain-wide c-Fos expression in male and female mice.

Oyaga MR, Serra I, Kurup D, Koekkoek SKE, Badura A
in Open biology 2023
DOI: 10.1098/rsob.220121

Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma.

Soloukey S, Verhoef L, Generowicz BS, De Zeeuw CI, Koekkoek SKE, Vincent AJPE, Dirven CMF, Harhangi BS, Kruizinga P
in Frontiers in surgery 2023
DOI: 10.3389/fsurg.2023.1153605

Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study

S. Soloukey, E. Collée, L. Verhoef, D.D. Satoer, C.M.F. Dirven, E.M. Bos, J.W. Schouten, B.S. Generowicz, F. Mastik, C.I. De Zeeuw, S.K.E. Koekkoek, A.J.P.E. Vincent, M. Smits, P. Kruizinga
in NeuroImage 2023
DOI: 10.1016/j.neuroimage.2023.120435

High-resolution micro-Doppler imaging during neurosurgical resection of an arteriovenous malformation: illustrative case

Soloukey, S., Verhoef, L., Jan van Doormaal, P., Generowicz, B. S., Dirven, C. M. F., De Zeeuw, C. I., Koekkoek, S. K. E., Kruizinga, P., Vincent, A. J. P. E., & Schouten, J. W.
in Journal Of Neurosurgery 2022
DOI: 10.3171/CASE22177

Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09613-3

Correction to: Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09619-x

Young Domestic Pigs Can Perform Pavlovian Eyeblink Conditioning.

Boele HJ, Joung S, Fil JE, Mudd AT, Fleming SA, Koekkoek SKE, Dilger RN
in Frontiers in behavioral neuroscience 2021
DOI: 10.3389/fnbeh.2021.690019

Fully integrating functional Ultrasound (fUS) into the onco-neurosurgical operating room: Towards a new real-time, high-resolution image-guided resection tool with multimodal potential

Soloukey S , Verhoef L , Mastik F , Generowicz B S , Bos E M , Harhangi B S, Collée K E , Satoer D D, Smits M , Dirven C M F , De Zeeuw C I , Koekkoek S K E , Vincent A J P E , Kruizinga P
in Neuro-Oncology 2021
DOI: 10.1093/neuonc/noab180.091

Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping

Soloukey Sadaf, Vincent Arnaud J. P. E., Satoer Djaina D., Mastik Frits, Smits Marion, Dirven Clemens M. F., Strydis Christos, Bosch Johannes G., van der Steen Antonius F. W., De Zeeuw Chris I., Koekkoek Sebastiaan K. E., Kruizinga Pieter
in Frontiers in Neuroscience 2020
DOI: 10.3389/fnins.2019.01384

NIMG-19. USING FUNCTIONAL ULTRASOUND (FUS) TO MAP BRAIN FUNCTIONALITY AND TUMOR VASCULATURE WITH MICROMETER-MILLISECOND PRECISION

Sadaf Soloukey, Arnaud J P E Vincent, Djaina D Satoer, Frits Mastik, Marion Smits, Clemens M F Dirven, Christos Strydis, Antonius F W van der Steen, Johannes G Bosch, Chris I De Zeeuw, Sebastiaan K E Koekkoek, Pieter Kruizinga
in Neuro-Oncology 2020
DOI: 10.1093/neuonc/noaa215.632

Joint Estimation of Hemodynamic Response and Stimulus Function in Functional Ultrasound Using Convolutive Mixtures.

Aybüke Erol, Simon Van Eyndhoven, Sebastiaan Koekkoek, Pieter Kruizinga, Borbála Hunyadi
in 2020
DOI: 10.1109/IEEECONF51394.2020.9443299
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Vacancies

There are currently no vacancies on our lab.