lab

Associative learning

Lab Head: Sebastiaan-Koekkoek

Lab Description







Associative learning is a broad category that includes many of our daily learning activities that involve the formation of associations among stimuli and/or responses. Classical (or Pavlovian) conditioning   is one of the forms of associative learning and is induced by a procedure in which a generally neutral stimulus is paired with a stimulus that generally elicits a response. Our lab evolved around this simple learning task.

We generally use eyeblink conditioning procedures  to study all aspects of associative learning but over the years we have continuously developed  new methods to broaden the scientific toolkit we can employ to understand this behavior. This development endeavor over time has led to a substantial engineering division in the lab consisting of electrical as well as computer engineers and scientists. 

Since 2019, together with Pieter Kruizinga and Christos Strydis (Head of the Neurocomputing Lab) we have started CUBE, a multidisciplinary center where we develop functional ultrasound into a new brain imaging method that will help us in getting the bigger picture of the awake behaving brain in both mice as well as humans.

Lab Members

Sebastiaan Koekkoek
Dr. Sebastiaan Koekkoek (SK)
Assistant Professor
Lab Head
Pieter Kruizinga
Dr. Pieter Kruizinga
Assistant Professor
Henk Jan Boele
Dr. Henk Jan Boele
Assistant Professor
Bastian Generowicz
ir. Bastian Generowicz
Phd Student
Luuk Verhoef
Luuk Verhoef
Phd Student
Sadaf Soloukey
Sadaf Soloukey
Phd Student
Farnaz Nassirinia
Ir. Farnaz Nassirinia
Phd Student
Didem Dogan Baskaya
Didem Dogan Baskaya
Phd Student
Gillian de Zwart
Gillian de Zwart
Master Student
Sara Milosevska
Sara Milosevska
Master Student
Ting Fang Soong
Ting Fang Soong
Master Student
Michael Brown
Michael Brown
Scientific Researcher
Max Engelen
Max Engelen
Research Technician
Erol Aybuke
Erol Aybuke
Scientific Researcher
Stephanie Dijkhuizen
Stephanie Dijkhuizen
Research Technician

Recent Publications

Functional imaging of the exposed brain

Soloukey Sadaf, Vincent Arnaud J. P. E., Smits Marion, De Zeeuw Chris I., Koekkoek Sebastiaan K. E., Dirven Clemens M. F., Kruizinga Pieter
in Frontiers in Neuroscience 2023
DOI: 10.3389/fnins.2023.1087912

High-resolution micro-Doppler imaging during neurosurgical resection of an arteriovenous malformation: illustrative case

Soloukey, S., Verhoef, L., Jan van Doormaal, P., Generowicz, B. S., Dirven, C. M. F., De Zeeuw, C. I., Koekkoek, S. K. E., Kruizinga, P., Vincent, A. J. P. E., & Schouten, J. W.
in Journal Of Neurosurgery 2022
DOI: 10.3171/CASE22177

Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09613-3

Correction to: Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.

Erol A, Soloukey C, Generowicz B, van Dorp N, Koekkoek S, Kruizinga P, Hunyadi B
in Neuroinformatics 2022
DOI: 10.1007/s12021-022-09619-x

Young Domestic Pigs Can Perform Pavlovian Eyeblink Conditioning.

Boele HJ, Joung S, Fil JE, Mudd AT, Fleming SA, Koekkoek SKE, Dilger RN
in Frontiers in behavioral neuroscience 2021
DOI: 10.3389/fnbeh.2021.690019

Fully integrating functional Ultrasound (fUS) into the onco-neurosurgical operating room: Towards a new real-time, high-resolution image-guided resection tool with multimodal potential

Soloukey S , Verhoef L , Mastik F , Generowicz B S , Bos E M , Harhangi B S, Collée K E , Satoer D D, Smits M , Dirven C M F , De Zeeuw C I , Koekkoek S K E , Vincent A J P E , Kruizinga P
in Neuro-Oncology 2021
DOI: 10.1093/neuonc/noab180.091

How to Identify Responders and Nonresponders to Dorsal Root Ganglion-Stimulation Aimed at Eliciting Motor Responses in Chronic Spinal Cord Injury: Post Hoc Clinical and Neurophysiological Tests in a Case Series of Five Patients.

Soloukey S, Drenthen J, Osterthun R, de Vos CC, De Zeeuw CI, Huygen FJPM, Harhangi BS
in Neuromodulation : journal of the International Neuromodulation Society 2021
DOI: 10.1111/ner.13379

Dorsal Root Ganglion (DRG) Versatile Stimulator Prototype Developed for Use in Locomotion Recovery Early Clinical Trials.

Konstantina Kolovou-Kouri, Sadaf Soloukey, Frank J. P. M. Huygen, Biswadjiet S. Harhangi, Wouter A. Serdijn, Vasiliki Giagka
in 2021
DOI: 10.1109/NER49283.2021.9441101

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice.

Kathe C, Michoud F, Schönle P, Rowald A, Brun N, Ravier J, Furfaro I, Paggi V, Kim K, Soloukey S, Asboth L, Hutson TH, Jelescu I, Philippides A, Alwahab N, Gandar J, Huber D, De Zeeuw CI, Barraud Q, Huang Q, Lacour SP, Courtine G
in Nature biotechnology 2021
DOI: 10.1038/s41587-021-01019-x

A response to “Living with a fragmented body”: a qualitative study on perceptions about body changes after a spinal cord injury

Soloukey S., Prins A. W., ZwartH., Slatman J.
in Spinal Cord 2021
DOI: 10.1038/s41393-021-00727-0

Securing Implantable Medical Devices Using Ultrasound Waves.

Muhammad Ali Siddiqi, Robert H. S. H. Beurskens, Pieter Kruizinga, Chris I. De Zeeuw, Christos Strydis
in IEEE Access 2021
DOI: 10.1109/ACCESS.2021.3083576

Multiple Measurement Vector Model for Sparsity-Based Vascular Ultrasound Imaging.

Didem Dogan, Pieter Kruizinga, Johannes G. Bosch, Geert Leus
in 2021
DOI: 10.1109/SSP49050.2021.9513860

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

Beekhof GC, Osório C, White JJ, van Zoomeren S, van der Stok H, Xiong B, Nettersheim IH, Mak WA, Runge M, Fiocchi FR, Boele HJ, Hoebeek FE, Schonewille M
in eLife 2021
DOI: 10.7554/eLife.63668

Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain.

Pisano TJ, Dhanerawala ZM, Kislin M, Bakshinskaya D, Engel EA, Hansen EJ, Hoag AT, Lee J, de Oude NL, Venkataraju KU, Verpeut JL, Hoebeek FE, Richardson BD, Boele HJ, Wang SS
in Cell reports 2021
DOI: 10.1016/j.celrep.2021.109721

Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping

Soloukey Sadaf, Vincent Arnaud J. P. E., Satoer Djaina D., Mastik Frits, Smits Marion, Dirven Clemens M. F., Strydis Christos, Bosch Johannes G., van der Steen Antonius F. W., De Zeeuw Chris I., Koekkoek Sebastiaan K. E., Kruizinga Pieter
in Frontiers in Neuroscience 2020
DOI: 10.3389/fnins.2019.01384
show more publications

Vacancies

There are currently no vacancies on our lab.