Edwin Mientjes

contact

  • e.mientjes@erasmusmc.nl
  • +31 010 70 43565
  • Room: Ee-1491
  • Dr. Molewaterplein 40, Faculty Building, Rotterdam, The Netherlands

Dr. Edwin Mientjes (E.)

Publications

1. A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides.

Smeenk H, Lendemeijer B, Buurma MG, Forgione MA, Slump DE, Monshouwer RA, Wallaard I, Mientjes EJ, Hoogendijk WJG, Elgersma Y, de Vrij FMS, Kushner SA
in Scientific reports 2026
DOI: 10.1038/s41598-026-41197-9

2. UBE3A isoform-selective and non-selective contributions to Angelman syndrome phenotypes.

Krzeski JC, Mientjes EJ, Judson MC, Dong G, Hipp RI, Lien KH, Gu B, Philpot BD, Elgersma Y
in Molecular psychiatry 2026
DOI: 10.1038/s41380-026-03468-9

3. A robust method for primary cerebellar culture and genetic manipulation of Purkinje cells from postnatal mice

Heiling Lu, Friederike Stephani, Myrna Aulia, Edwin Mientjes, Martijn Schonewille, Catarina Osório
in Journal of Neuroscience Methods 2026
DOI: 10.1016/j.jneumeth.2025.110627 PDF

4. UBE3A reinstatement restores behaviorand proteome in an Angelman syndrome mouse model of imprinting defects.

Milazzo C, Narayanan R, Badillo S, Wang S, Almand R, Monshouwer R, Tzouros M, Golling S, Mientjes E, Chamberlain S, Kremer T, Elgersma Y
in Molecular autism 2025
DOI: 10.1186/s13229-025-00675-z

5. Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function.

Avagliano Trezza R, Punt AM, Mientjes E, van den Berg M, Zampeta FI, de Graaf IJ, van der Weegen Y, Demmers JAA, Elgersma Y, Distel B
in Scientific reports 2021
DOI: 10.1038/s41598-021-82319-9

6. Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model.

Milazzo C, Mientjes EJ, Wallaard I, Rasmussen SV, Erichsen KD, Kakunuri T, van der Sman ASE, Kremer T, Miller MT, Hoener MC, Elgersma Y
in JCI insight 2021
DOI: 10.1172/jci.insight.145991

7. Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.

Pandya NJ, Wang C, Costa V, Lopatta P, Meier S, Zampeta FI, Punt AM, Mientjes E, Grossen P, Distler T, Tzouros M, Martí Y, Banfai B, Patsch C, Rasmussen S, Hoener M, Berrera M, Kremer T, Dunkley T, Ebeling M, Distel B, Elgersma Y, Jagasia R
in Cell reports. Medicine 2021
DOI: 10.1016/j.xcrm.2021.100360

8. Angelman Syndrome: From Mouse Models to Therapy.

Rotaru DC, Mientjes EJ, Elgersma Y
in Neuroscience 2020
DOI: 10.1016/j.neuroscience.2020.02.017

9. Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.

Sonzogni M, Zhai P, Mientjes EJ, van Woerden GM, Elgersma Y
in Molecular autism 2020
DOI: 10.1186/s13229-020-00376-9

10. The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

Tonazzini I, Van Woerden GM, Mientjes EJ, Elgersma Y, Cecchini M
in Mol Autism 2019
DOI: 10.1186/s13229-019-0293-1
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