The neuropeptide oxytocin plays an essential role in dynamically and reversibly adapting circuit function to physiological states like social interaction, reproduction, parenting, and feeding. Oxytocin also carries transient roles during sensitive periods of development when neural circuits are first established. While the cerebellum is part of the distributed circuits that control social and homeostatic functions, little is known about how oxytocin shapes cerebellar function. We employ transcriptomic analysis and electrophysiology to identify oxytocin target neurons in the adult and developing cerebellar cortex of mice. We find that oxytocin modulates input integration in the granule cell layer in adult mice and transiently drives activity in GABAergic neuron population in early postnatal development
Organizer
Catarina Osorio
c.osorio@erasmusmc.nl