SEMINAR

Movement, sensation, and expectation converge in mouse auditory cortex

30/05/2022
5:00pm - 6:30pm
online
Speakers Website
Dr. David Schneider

Many of the sensations experienced by an organism are caused by their own actions, yet it remains largely unknown how the brain recognizes self-generated sensations. We trained mice to expect the precisely timed acoustic outcome of a forelimb movement using a closed-loop sound-generating lever. Dense neuronal recordings in the auditory cortex revealed suppression of responses to self-generated sounds that was specific to the expected acoustic features, specific to a precise time within the movement, and specific to the movement that was coupled to sound during training. Recording in the absence of sound revealed movement-related signals that encoded the expected frequency and time of the omitted sound. Together, these findings reveal that predictive processing in the mouse auditory cortex is consistent with a learned internal model linking a specific action to its temporally precise acoustic outcome.


Organizer

Aaron Wong
a.wong@erasmusmc.nl